منابع مشابه
Longevity Genes Revealed by Integrative Analysis of Isoform-Specific daf-16/FoxO Mutants of Caenorhabditis elegans
FoxO transcription factors promote longevity across taxa. How they do so is poorly understood. In the nematode Caenorhabditis elegans, the A- and F-isoforms of the FoxO transcription factor DAF-16 extend life span in the context of reduced DAF-2 insulin-like growth factor receptor (IGFR) signaling. To elucidate the mechanistic basis for DAF-16/FoxO-dependent life span extension, we performed an...
متن کاملSMK-1, an Essential Regulator of DAF-16-Mediated Longevity
Insulin/IGF-1 signaling (IIS) regulates aging in worms, flies, and mice through a well-characterized, highly conserved core set of components. IIS also regulates early developmental decisions, the reproductive status of the animal, innate immunity, and stress-resistance functions. In C. elegans, the sole insulin/IGF-1 receptor, DAF-2, negatively regulates the FOXO transcription factor, DAF-16. ...
متن کاملDAF-16/FOXO Transcription Factor in Aging and Longevity
Aging is associated with age-related diseases and an increase susceptibility of cancer. Dissecting the molecular mechanisms that underlie aging and longevity would contribute to implications for preventing and treating the age-dependent diseases or cancers. Multiple signaling pathways such as the insulin/IGF-1 signaling pathway, TOR signaling, AMPK pathway, JNK pathway and germline signaling ha...
متن کاملDAF-16 and PQM-1: Partners in longevity
years ago it was discovered that loss of insulin/IGF-1-like signaling (IIS) – such as occurs in daf-2(mutants ts – dramatically extends longevity in the nematode C. elegans via the FOXO transcription factor DAF-16 [1-3]. Under favorable conditions, DAF-16 remains cytosolic and transcriptionally inactive[2-4]; under stress, it is driven into the nucleus, leading to both up-regulation and down-re...
متن کاملIdentification of a DAF-16 Transcriptional Target Gene, scl-1, that Regulates Longevity and Stress Resistance in Caenorhabditis elegans
In Caenorhabditis elegans, an insulin-like signaling pathway, which includes the daf-2 and age-1 genes, controls longevity and stress resistance. Downregulation of this pathway activates the forkhead transcription factor DAF-16, whose transcriptional targets are suggested to play an essential role in controlling the phenotypes governed by this pathway. We have surveyed the genes that have the D...
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ژورنال
عنوان ژورنال: Nature
سال: 2010
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature09184